PU.1 Regulates Cathepsin S Expression in Professional APCs

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PU.1 regulates cathepsin S expression in professional APCs.

Cathepsin S (CTSS) is a cysteine protease that is constitutively expressed in APCs and mediates processing of MHC class II-associated invariant chain. CTSS and the Ets family transcription factor PU.1 are highly expressed in cells of both myeloid (macrophages and dendritic cells) and lymphoid (B lymphocytes) lineages. Therefore, we hypothesized that PU.1 participates in the transcriptional regu...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2005

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.176.1.275